MOTS C peptide overview MOTS C peptide, also known as mitochondrial open reading frame of the 12S rRNA type c (MOTS-c), is a short mitochondrial-encoded peptide that has gained significant attention due to its potential role in improving metabolic health and extending lifespan. Initially discovered in 2015, MOTS-c has been found to activate AMP-activated protein kinase (AMPK) and improve insulin sensitivity, …